![WechatIMG216.jpg](https://static.wixstatic.com/media/105bd6_45b4f5b4fe4949f4ba2d24f872c140d4~mv2.jpg/v1/fill/w_460,h_480,al_c,q_80,usm_0.66_1.00_0.01,enc_auto/WechatIMG216.jpg)
Jun-Jie (Gogo) Liu
PI
Associate professor
Beijing Advanced Innovation Center for Structural Biology
Center of Life Sciences
School of Life Sciences
Tsinghua University
junjiegogoliu(at)tsinghua.edu.cn
Please replace (at) with @ for contact
Current Members
![WechatIMG113_edited_edited.jpg](https://static.wixstatic.com/media/105bd6_7616b9cb765249d69ab4fca054e7a1cc~mv2.jpg/v1/fill/w_62,h_80,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/WechatIMG113_edited_edited.jpg)
Pujuan Deng
Postdoc
Email: dengpj(at)mail.tsinghua.edu.cn
Research Topic:
Molecular mechanisms and applications of novel nucleic acid manipulation tool. Currently, it is very inefficient to achieve gene-specific insertion based on the traditional CRISPR system. Therefore, I want to solve structures of the tool in order to understand the molecular mechanisms by cryo-EM, and combine multidisciplinary methods to develop its multi-functional applications.
![WechatIMG4.jpg](https://static.wixstatic.com/media/105bd6_e80ef663557f406bbc8216652d5152a0~mv2.jpg/v1/crop/x_0,y_50,w_914,h_1179/fill/w_62,h_80,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/WechatIMG4.jpg)
Shouyue Zhang
Postdoc
Email: shouyuezhang(at)mail.tsinghua.edu.cn
Research Topic:
Identification and development of new CRISPR-Cas nuclease systems from environmental genome samples by using bioinformatics and structural biology methods.
To explore the biological function and clinical therapeutic application of lncRNA.
![2391700026304_.pic_hd.jpg](https://static.wixstatic.com/media/105bd6_7085ecc7098d41ae87923f07bd7e702f~mv2.jpg/v1/fill/w_56,h_80,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/2391700026304__pic_hd.jpg)
Shuai Jin
Postdoc
Email: shuaijin(at)mail.tsinghua.edu.cn
Research Topic:
I) Directed evolution of the entire human or plant genomes.
II) Specificity of precise genome editing systems.
III) Evolutionary trajectory of CRISPR systems.
![1111700142816__edited.jpg](https://static.wixstatic.com/media/105bd6_bab27e1dee9d4d2f9e2417fbb497c2a0~mv2.jpg/v1/fill/w_52,h_80,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/1111700142816__edited.jpg)
Yuanyuan Jiang
Postdoc
Email: jiangyyuan(at)mail.tsinghua.edu.cn
Research Topic:
(1) Exploring the mechanisms and biological functions of ribozymes;
(2) Developing novel RNA-based nucleic acid manipulation tools within animal and plant organisms.
![WechatIMGc469ce942b263a4665492935afe24457.jpeg](https://static.wixstatic.com/media/105bd6_b4f89848337448c29330ce090d5d07ff~mv2.jpeg/v1/fill/w_60,h_80,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/WechatIMGc469ce942b263a4665492935afe24457.jpeg)
Zheng Zhang
Postdoc
Email: zhengzhang61(at)mail.tsinghua.edu.cn
Research Topic:
Developing and optimizing RNA-based nucleic acid editing tools.
Editing is not manipulation but only guidance for the genome to fix itself.
![mmexport1605609323137[1].jpg](https://static.wixstatic.com/media/105bd6_7cb6021337b847e7ab5fe2128ef44d36~mv2.jpg/v1/fill/w_60,h_80,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/mmexport1605609323137%5B1%5D.jpg)
Danyuan Li
Ph. D. Candidate
Email: li-dy18(at)mails.tsinghua.edu.cn
Research Topic:
I’m focusing on the structural analysis of some new Cas proteins in Class II, type V Cas systems and exploring the evolutionary association between the Cas phylogeny and tertiary structure of the tracrRNA
![WechatIMG580.jpg](https://static.wixstatic.com/media/105bd6_a3dc9418f3cf46dd83d4cff49d2a687d~mv2.jpg/v1/fill/w_63,h_42,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/WechatIMG580.jpg)
Jingbo Jiang
Ph. D. Candidate - joint PhD. student
Email: jiangjb18(at)mails.tsinghua.edu.cn
Research Topic:
(1) Studying on physiological RNA substrate of RNA exosome complex in direct-access route by biochemistry and structure;
(2) Exploring new cofactors of RNA exosome complex in yeast and human cells and determining the complex structures.
![图片 1.png](https://static.wixstatic.com/media/105bd6_5e36b1a63b3a42f88b644eacea32c9ab~mv2.png/v1/crop/x_0,y_0,w_358,h_450/fill/w_62,h_78,al_c,q_85,usm_0.66_1.00_0.01,blur_2,enc_auto/%E5%9B%BE%E7%89%87%201.png)
Yun Yang
Ph. D. Candidate
Email: yangyun19(at)mails.tsinghua.edu.cn
Research Topic:
My major research interest is the direct evolution of Cas proteins in mammalian cells to improve gene editing efficiency based on structural optimization.
![WechatIMG554.jpg](https://static.wixstatic.com/media/105bd6_62a4b8384af243e9a4db9d9dff2ffda9~mv2.jpg/v1/crop/x_16,y_0,w_210,h_264/fill/w_62,h_78,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/WechatIMG554.jpg)
Mingzhe Xia
Ph. D. Candidate- joint PhD. student
Email: xmz19(at)mails.tsinghua.edu.cn
Research Topic:
(1) Study the mechanism of low phosphorus response and root hair development of Arabidopsis.
(2) Exploring the biochemical properties of plant transposase and their effects on biological functions.
![IMG_5832.JPG](https://static.wixstatic.com/media/105bd6_b7874480be594c0c805350d58c279944~mv2.jpg/v1/fill/w_60,h_80,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/IMG_5832_JPG.jpg)
Chengping Li
Ph. D. Candidate
Email: lcp20(at)mails.tsinghua.edu.cn
Research Topic:
Mining and unearthing novel CRISPR-Cas and other systems with the potential of genome editing by bioinformatics methods.
Determining the 3D structures of proteins and RNAs using Cryo-EM.
![6181624421943__edited.jpg](https://static.wixstatic.com/media/105bd6_fc0b97bb8c7e490aaa0e60205d81d1e9~mv2.jpg/v1/crop/x_69,y_87,w_433,h_548/fill/w_61,h_78,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/6181624421943__edited.jpg)
Hanzhou Zhu
Ph. D. Candidate
Email: zhz20(at)mails.tsinghua.edu.cn
Research Topic:
I am mainly focusing on these parts,
I) Using Cryo-EM to analyze RNA 3D structure and mechanism.
II) Developing a new method for RNA purification from in vivo system.
III) RNA degradation by the exosome.
![IMG_5835.JPG](https://static.wixstatic.com/media/105bd6_0b71e8d354d84e399a18188a249d8f0a~mv2.jpg/v1/fill/w_60,h_80,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/IMG_5835_JPG.jpg)
Ao Sun
Ph. D. Candidate
Email: sunao20(at)mails.tsinghua.edu.cn
Research Topic:
1) Developing new CRISPR-Cas gene editing tools
2) Searching novel CRISPR-Cas associated factors
3) Exploring other potential gene editing tools
![671653915824_.pic.jpg](https://static.wixstatic.com/media/105bd6_b8f778ef760a4143803f5f4cf15ef121~mv2.jpg/v1/crop/x_0,y_53,w_1280,h_1600/fill/w_62,h_77,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/671653915824__pic.jpg)
Shunqing Tan
Ph. D. Candidate
Email: tansq21(at)mails.tsinghua.edu.cn
Research Topic:
Exploring the mechanism of nuclease activities and developing novel gene editing tools.
![mmexport1605609348461[1].jpg](https://static.wixstatic.com/media/105bd6_07221a6d898548b6911c5e7fe70fc4b5~mv2.jpg/v1/crop/x_0,y_68,w_668,h_833/fill/w_62,h_77,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/mmexport1605609348461%5B1%5D.jpg)
Zixian Liu
Ph. D. Candidate
Email: liuzx21(at)mails.tsinghua.edu.cn
Research Topic:
My research focuses on the biochemistry analysis and identification of introns to explore their biological functions and their potential to be used in nucleic acid manipulation.
![2341686386549_.pic_hd.jpg](https://static.wixstatic.com/media/105bd6_0c0e9e754e684561a0686bc9b6a91a23~mv2.jpg/v1/crop/x_0,y_153,w_2039,h_2549/fill/w_62,h_77,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/2341686386549__pic_hd.jpg)
Longqi Li
Ph. D. Student
Email: lilq22(at)mails.tsinghua.edu.cn
Research Topic:
Detection of gene-editing potential of novel nucleases in mammalian cells and Development of the next-generation gene-manipulating toolbox.
![WechatIMG582.jpg](https://static.wixstatic.com/media/105bd6_b02045a3a07e46fd9820dcaa95ff21a7~mv2.jpg/v1/crop/x_0,y_66,w_914,h_1147/fill/w_62,h_77,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/WechatIMG582.jpg)
Shuo Lin
Ph. D. Student
Email:lins23@mails.tsinghua.edu.cn
Research Topic:
Mining new ribozyme in matagenomic database and using structual biology approach to solve the mechenism
![WechatIMG558.jpg](https://static.wixstatic.com/media/105bd6_316b4502b56445979a9ce069f535b33d~mv2.jpg/v1/crop/x_130,y_0,w_1020,h_1280/fill/w_62,h_77,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/WechatIMG558.jpg)
Gaoli Wang
Ph. D. Student
Email: wanggl23(at)mails.tsinghua.edu.cn
Research Topic:
Searching for ribozymes with novel functions and exploring their applications as biological tools
![WechatIMG111.jpg](https://static.wixstatic.com/media/105bd6_caf2d0d363f944189c9033d4a30ec197~mv2.jpg/v1/crop/x_424,y_362,w_1611,h_2018/fill/w_62,h_77,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/WechatIMG111.jpg)
Shulin Jin
Ph. D. Student
Email: jsl23(at)mails.tsinghua.edu.cn
Research Topic:
Exploring the mechanism of novel RNA-involved nuclease system by using biochemistry methods.
![WechatIMG21.jpg](https://static.wixstatic.com/media/105bd6_fadb8a7778184fa784a33640064519bd~mv2.jpg/v1/crop/x_0,y_61,w_1280,h_1606/fill/w_62,h_77,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/WechatIMG21.jpg)
Ruihan Zhang
Ph. D. Student
Email: ruihan-z23(at)mails.tsinghua.edu.cn
Research Topic:
Leverage bioinformatics and AI techs to integrate sequence, structure, and evolutionary information for developing next-generation gene editing tools
![WechatIMG598.jpg](https://static.wixstatic.com/media/105bd6_0009461df7034f68adefdb4f8b73eeaf~mv2.jpg/v1/crop/x_99,y_0,w_773,h_970/fill/w_62,h_77,al_c,q_80,usm_0.66_1.00_0.01,blur_2,enc_auto/WechatIMG598.jpg)
Zhonghao Zhang
Research assitant
Email: zhonghaozhang2022(at)163.com
I graduated from Ocean University of China with a master's degree. I am currently working as a research assistant. I am easy-going, sincere, ready to help others, serious and responsible for work.
Postdocs and Ph.D. Candidates...
![图片 1.png](https://static.wixstatic.com/media/105bd6_426a11efd00b46059d5be94e53b2cc2b~mv2.png/v1/fill/w_69,h_27,al_c,q_85,usm_0.66_1.00_0.01,blur_2,enc_auto/%E5%9B%BE%E7%89%87%201.png)
Alumni
![WechatIMG105_edited.jpg](https://static.wixstatic.com/media/105bd6_6bedd2caa2ee447289b3de048a07dcc7~mv2.jpg/v1/crop/x_167,y_0,w_658,h_822/fill/w_120,h_150,al_c,q_80,usm_0.66_1.00_0.01,blur_3,enc_auto/WechatIMG105_edited.jpg)
Dandan Sun
2020.4-2021.7, Lab Manager
Current, Laboratory engineer
![mmexport1605609293265[1].jpg](https://static.wixstatic.com/media/105bd6_4e6a71bbf7c94e56928c53a67238aacf~mv2.jpg/v1/fill/w_113,h_150,al_c,q_80,usm_0.66_1.00_0.01,blur_3,enc_auto/mmexport1605609293265%5B1%5D.jpg)
Xinyi Wu
2020.10-2021.4, Visiting Student
Current, JiMei University
![mmexport1605609264211[1].jpg](https://static.wixstatic.com/media/105bd6_6d67cfb2c1764cac8baba787c8ed61fd~mv2.jpg/v1/crop/x_415,y_357,w_451,h_544/fill/w_124,h_150,al_c,q_80,usm_0.66_1.00_0.01,blur_3,enc_auto/mmexport1605609264211%5B1%5D.jpg)
Zhuoyan Hai
2020.10-2021.8, Visiting Student
Current, Ph.D. in Tsinghua University
![微信图片_20201117192807.jpg](https://static.wixstatic.com/media/105bd6_a698893c855741fab0d90c77fdb4a917~mv2.jpg/v1/crop/x_0,y_26,w_480,h_587/fill/w_123,h_150,al_c,q_80,usm_0.66_1.00_0.01,blur_3,enc_auto/%E5%BE%AE%E4%BF%A1%E5%9B%BE%E7%89%87_20201117192807.jpg)
Jiahui Zhao
2020.10-2021.8, Visiting Scholar
Current, master student
in Columbia University
![IMG_5833.JPG](https://static.wixstatic.com/media/105bd6_9a72ff60c17e4a7d8c0b80de43dd61d7~mv2.jpg/v1/crop/x_0,y_17,w_413,h_523/fill/w_124,h_157,al_c,q_80,usm_0.66_1.00_0.01,blur_3,enc_auto/IMG_5833_JPG.jpg)
2021.5-2021.11, Visiting Scholar
Tingxuan Yang
![WechatIMG115.jpeg](https://static.wixstatic.com/media/105bd6_b42d44e079044151bd3357bfa1b7156a~mv2.jpeg/v1/crop/x_0,y_0,w_720,h_926/fill/w_124,h_160,al_c,q_80,usm_0.66_1.00_0.01,blur_3,enc_auto/WechatIMG115.jpeg)
Yuqian Zhao
2020.5-2022.6, Postdoc
![211637750884_.pic.jpg](https://static.wixstatic.com/media/105bd6_3540380c3dcf495ca4f94becc94d1239~mv2.jpg/v1/crop/x_0,y_61,w_404,h_485/fill/w_125,h_150,al_c,q_80,usm_0.66_1.00_0.01,blur_3,enc_auto/211637750884__pic.jpg)
Zhihao Jing
2021.9-2022.7, Visiting Scholar
Current, Tibet Agricultural and Animal Husbandry University
![11651630588499_.pic_hd.jpg](https://static.wixstatic.com/media/105bd6_f6d0de8915b440ebb45bc1fadb5808b5~mv2.jpg/v1/crop/x_141,y_299,w_572,h_702/fill/w_125,h_153,al_c,q_80,usm_0.66_1.00_0.01,blur_3,enc_auto/11651630588499__pic_hd.jpg)
Qiaoyang Ma
2021.9-2022.8, Visiting Student
Current, Ph.D. in Tsinghua University
![图片 1.png](https://static.wixstatic.com/media/105bd6_83e8232aea6b42c1a3613688646eb8eb~mv2.png/v1/crop/x_0,y_59,w_866,h_1067/fill/w_124,h_153,al_c,q_85,usm_0.66_1.00_0.01,blur_3,enc_auto/%E5%9B%BE%E7%89%87%201.png)
Yutao Chen
2021.10-2022.7, Visiting Student
Current, Ph.D. in Tsinghua University
![WechatIMG52.jpeg](https://static.wixstatic.com/media/105bd6_dca8e678264c4a389acc523c7b0c9d1f~mv2.jpeg/v1/crop/x_0,y_238,w_1728,h_2115/fill/w_125,h_153,al_c,q_80,usm_0.66_1.00_0.01,blur_3,enc_auto/WechatIMG52.jpeg)
Zhihang Chen
2022.3-2024.3, Postdoc
Current,the Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Science
![WechatIMG581.jpg](https://static.wixstatic.com/media/105bd6_5db19e4fc7ad4837a1770f2a34d113aa~mv2.jpg/v1/crop/x_366,y_0,w_865,h_1059/fill/w_125,h_153,al_c,q_80,usm_0.66_1.00_0.01,blur_3,enc_auto/WechatIMG581.jpg)
SweeHong Ng
2023.9-2024.4, Visiting Student
Current, in Tsinghua University
![111624512324_.pic_hd.jpg](https://static.wixstatic.com/media/105bd6_9625f17bd07b439ca8a46ef0d6140171~mv2.jpg/v1/fill/w_251,h_320,al_c,q_80,usm_0.66_1.00_0.01,enc_auto/111624512324__pic_hd.jpg)
Min Li
Lab Manager
Email: mmli(at)mail.tsinghua.edu.cn
Undergraduate Students
![WechatIMG574.jpg](https://static.wixstatic.com/media/105bd6_a77310e4aa47487e943a53d5e3672024~mv2.jpg/v1/crop/x_0,y_140,w_806,h_999/fill/w_121,h_150,al_c,q_80,usm_0.66_1.00_0.01,blur_3,enc_auto/WechatIMG574.jpg)
Zhaofu Li
Tsinghua University
Grade 2021
![WechatIMG571.jpg](https://static.wixstatic.com/media/105bd6_23c6cd9eed63493ab38203a8585ad2e8~mv2.jpg/v1/crop/x_102,y_536,w_532,h_655/fill/w_122,h_150,al_c,q_80,usm_0.66_1.00_0.01,blur_3,enc_auto/WechatIMG571.jpg)
Qiyu Yang
Tsinghua University
Grade 2021
![WechatIMG0e9b35c13ea760c575db04c167130168.jpeg](https://static.wixstatic.com/media/105bd6_0325ef89bd1e40a399e57b458ddd6f49~mv2.jpeg/v1/crop/x_570,y_0,w_1064,h_1276/fill/w_125,h_150,al_c,q_80,usm_0.66_1.00_0.01,blur_3,enc_auto/WechatIMG0e9b35c13ea760c575db04c167130168.jpeg)
Yun Liu
Tsinghua University
Grade 2021
![WechatIMG573.jpg](https://static.wixstatic.com/media/105bd6_c57e36ff3a784749a4f559f662ad8909~mv2.jpg/v1/crop/x_0,y_22,w_926,h_1109/fill/w_125,h_150,al_c,q_80,usm_0.66_1.00_0.01,blur_3,enc_auto/WechatIMG573.jpg)
Xiaozheng Yang
Tsinghua University
Grade 2020
![WechatIMG595.jpg](https://static.wixstatic.com/media/105bd6_7ac918db30424653aad4b626b56bb295~mv2.jpg/v1/crop/x_123,y_185,w_731,h_918/fill/w_119,h_150,al_c,q_80,usm_0.66_1.00_0.01,blur_3,enc_auto/WechatIMG595.jpg)
Tsinghua University
Grade 2023
Runheng Zhang
![WechatIMG575.jpg](https://static.wixstatic.com/media/105bd6_de7774f7f0cd4dc3b4c89d2715bd8413~mv2.jpg/v1/crop/x_0,y_52,w_960,h_1175/fill/w_123,h_150,al_c,q_80,usm_0.66_1.00_0.01,blur_3,enc_auto/WechatIMG575.jpg)
Matylda Zuzanna Klos
University of Manchester
Grade 2021
![WechatIMG583.jpg](https://static.wixstatic.com/media/105bd6_655588e4b88f4c8da9228e93f137320b~mv2.jpg/v1/crop/x_0,y_26,w_960,h_1229/fill/w_117,h_150,al_c,q_80,usm_0.66_1.00_0.01,blur_3,enc_auto/WechatIMG583.jpg)
Jiantao Zhang
Tsinghua University
Grade 2023
![WechatIMG560.jpg](https://static.wixstatic.com/media/105bd6_2fd46563f7274ecf89cccb59d5c5653d~mv2.jpg/v1/crop/x_0,y_48,w_847,h_1037/fill/w_123,h_150,al_c,q_80,usm_0.66_1.00_0.01,blur_3,enc_auto/WechatIMG560.jpg)
Yue Zhang
Nanjing Agricultural University
Grade 2020
![WechatIMG589.jpg](https://static.wixstatic.com/media/105bd6_957db7f0c85b440bbc747ecd483c0c6e~mv2.jpg/v1/crop/x_0,y_2,w_1043,h_1277/fill/w_123,h_150,al_c,q_80,usm_0.66_1.00_0.01,blur_3,enc_auto/WechatIMG589.jpg)
Yuntian Yang
Lanzhou University
Grade 2020
![WechatIMG576.jpg](https://static.wixstatic.com/media/105bd6_ed2da6eb81244ed29aa3c4a8a49b7959~mv2.jpg/v1/crop/x_0,y_105,w_875,h_1071/fill/w_123,h_150,al_c,q_80,usm_0.66_1.00_0.01,blur_3,enc_auto/WechatIMG576.jpg)
Wenwen Wang
Sun Yat-sen University
Grade 2019
![WechatIMG600.jpg](https://static.wixstatic.com/media/105bd6_d871ed7ce6f04eb48557a44eaf9b917d~mv2.jpg/v1/crop/x_104,y_221,w_719,h_882/fill/w_122,h_150,al_c,q_80,usm_0.66_1.00_0.01,blur_3,enc_auto/WechatIMG600.jpg)
Yang Yi
Sichuan University
Grade 2020